Detalhe da pesquisa
1.
Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis.
Cell
; 181(4): 848-864.e18, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32298651
2.
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.
Cell
; 182(2): 429-446.e14, 2020 07 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32526206
3.
MagicalRsq-X: A cross-cohort transferable genotype imputation quality metric.
Am J Hum Genet
; 111(5): 990-995, 2024 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-38636510
4.
Genetic regulators of sputum mucin concentration and their associations with COPD phenotypes.
PLoS Genet
; 19(6): e1010445, 2023 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-37352370
5.
Genetic variation in severe cystic fibrosis liver disease is associated with novel mechanisms for disease pathogenesis.
Hepatology
; 2024 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-38536042
6.
Proximal and Distal Bronchioles Contribute to the Pathogenesis of Non-Cystic Fibrosis Bronchiectasis.
Am J Respir Crit Care Med
; 209(4): 374-389, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38016030
7.
SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13.
Proc Natl Acad Sci U S A
; 119(16): e2119680119, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35353667
8.
Genetic Modifiers of Cystic Fibrosis Lung Disease Severity: Whole-Genome Analysis of 7,840 Patients.
Am J Respir Crit Care Med
; 207(10): 1324-1333, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36921087
9.
Assembly and organization of the N-terminal region of mucin MUC5AC: Indications for structural and functional distinction from MUC5B.
Proc Natl Acad Sci U S A
; 118(39)2021 09 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-34548396
10.
Prolonged, physiologically relevant nicotine concentrations in the airways of smokers.
Am J Physiol Lung Cell Mol Physiol
; 324(1): L32-L37, 2023 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36342131
11.
Reduced quantity and function of pneumococcal antibodies are associated with exacerbations of COPD in SPIROMICS.
Clin Immunol
; 250: 109324, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37030524
12.
Prevalence and Mechanisms of Mucus Accumulation in COVID-19 Lung Disease.
Am J Respir Crit Care Med
; 206(11): 1336-1352, 2022 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35816430
13.
The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions.
J Allergy Clin Immunol
; 149(2): 488-516.e9, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34848210
14.
Treatment of cystic fibrosis airway cells with CFTR modulators reverses aberrant mucus properties via hydration.
Eur Respir J
; 59(2)2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34172469
15.
Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.
Am J Respir Crit Care Med
; 203(10): 1275-1289, 2021 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33321047
16.
Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers.
Am J Respir Crit Care Med
; 203(8): 957-968, 2021 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33180550
17.
Genetic association and transcriptome integration identify contributing genes and tissues at cystic fibrosis modifier loci.
PLoS Genet
; 15(2): e1008007, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30807572
18.
PrecISE: Precision Medicine in Severe Asthma: An adaptive platform trial with biomarker ascertainment.
J Allergy Clin Immunol
; 147(5): 1594-1601, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33667479
19.
Cystic Fibrosis Disease Modifiers: Complex Genetics Defines the Phenotypic Diversity in a Monogenic Disease.
Annu Rev Genomics Hum Genet
; 19: 201-222, 2018 08 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-29709203
20.
Phenotypic Characterization and Comparison of Cystic Fibrosis Rat Models Generated Using CRISPR/Cas9 Gene Editing.
Am J Pathol
; 190(5): 977-993, 2020 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-32084371